Decreased concentrations of SHBG were observed in overweight/obese (vs. lean) participants of the total sample and in overweight/obese adolescents with PCOS vs. the lean controls; however, this known relationship between SHBG and PCOS serves as a confounding factor for the relationship of SHBG with BMI and NAFLD. The gene discussed is SHBG; the disease is metabolic dysfunction-associated steatotic liver disease.