For example, the PICXEL (Perindopril/Indapamide in a double-blind Controlled study versus Enalapril in Left ventricular hypertrophy) and REASON (pREterax in regression of Arterial Stiffness in a contrOlled double-bliNd) trials showed that combination therapy with an ACE inhibitor/diuretic resulted in a significantly greater pronounced decrease in LV mass/hypertrophy than monotherapy with either an ACE inhibitor or a beta-blocker in hypertensives [85,86]. This evidence concerns the gene ACE and left ventricular hypertrophy.