The aims of this study were to investigate the natural history and growth pattern of hemangiomas by monitoring sonographic changes in size, alongside clinical factors, especially coagulation factors and Mac-2 binding protein glycosylation isomer (M2BPGi), which has been identified as a useful biomarker for assessment of liver fibrosis; to elucidate the factors that determine tumor growth; and to clarify the optimal management of patients with hemangiomas. Here, LGALS3 is linked to hemangioma.