It has been demonstrated that Theiler’s murine encephalomyelitis virus (TMEV), which leads to infection of central nervous system microglia and macrophages in mice, provoking a disorder similar to MS in humans, stimulates the expression of IL-23 via binding to TLR3 and TLR7, contributing to the development of experimental autoimmune MS [37]. This evidence concerns the gene IL23A and myeloid sarcoma.