IL22 and lung cancer: In addition, IL-22, IL-23, and IL-17 were significantly increased in the serum of lung cancer patients associated with IPF; the levels of these cytokines found in the serum show such significant values that they represent a parameter used to discriminate between lung cancer patients and the lung-cancer-associated IPF group; finally, the expression of IL-22, IL-23, and IL-17 was positively correlated with the degree of differentiation and tumor metastasis [51].