In this context, Chesshyre et al., 2022, and Coratti et al., 2022, [12,14] reported that DMD boys lacking both the Dp140 and Dp71 isoforms experienced a notable decrease in their motor function as assessed by the North Star Ambulatory Assessment (NSAA), highlighting the cumulative effect of brain dystrophin isoform loss on motor performance. Here, DMD is linked to Duchenne muscular dystrophy.