Finally, several of the identified proteins are important in AML: the JunB proto-oncogene (JUNB) and cyclin dependent kinase 12 (CDK12) are both regulators of AML stem cells, whereas filamin A (FLNA) is a fusion partner in AML-associated translocations (see Tables S7 and S8 for details). This evidence concerns the gene FLNA and acute myeloid leukemia.