CHI3L1 and acute myeloid leukemia: Finally, four of the identified proteins have been associated with prognosis or chemoresistance in previous AML studies (Table S7 first part): (i) transferrin receptor/iron metabolism is associated with prognosis in human AML; (ii) experimental studies suggest that fibronectin/integrin interactions are involved in AML chemoresistance; and (iii) both chitinase 3-like-1 (CHI3L1) and ANXA3 are associated with prognosis in human AML.