Concanamycin A altered the soluble mediator profile of primary AML cells also in the presence of cytarabine (Figure S7); when comparing the overall results, significantly decreased levels were seen for HGF, cystatin C and CXCL8, whereas the levels of GCSF1, MMP1, TNFα, IL6, IL1RA, IL1β, CXCL10, CXCL8, CXCL1, CCCL5, CCL4 and CCL3 were significantly increased. This evidence concerns the gene CST3 and acute myeloid leukemia.