Concanamycin A altered the soluble mediator profile of primary AML cells also in the presence of cytarabine (Figure S7); when comparing the overall results, significantly decreased levels were seen for HGF, cystatin C and CXCL8, whereas the levels of GCSF1, MMP1, TNFα, IL6, IL1RA, IL1β, CXCL10, CXCL8, CXCL1, CCCL5, CCL4 and CCL3 were significantly increased. The gene discussed is CCL4; the disease is acute myeloid leukemia.