Pheochromocytomas and abdominal paragangliomas stain positive for neuroendocrine markers CgA, SYP, ISL1, INSM1 and, often, GATA3; subsets of cases may display an intricate network of supporting sustentacular cells which are highlighted by an S100 or SOX10 stain [39]. Here, ISL1 is linked to hereditary pheochromocytoma-paraganglioma.