Both groups were comparable with respect to age, reasons for hyperprolactinemia, smoking, BMI, blood pressure, HOMA1-IR, and plasma levels of glucose, total prolactin, monomeric prolactin, macroprolactin, FSH, SHBG, thyrotropin, ACTH and IGF-1 (Table 1 and Table 2). The gene discussed is SHBG; the disease is hyperprolactinemia.