In a mouse study, vitamin D was shown to protect against traumatic brain injury via modulating TLR4/MyD88/NF-kappa B-signaling pathways, and vitamin D deficiency is associated with poor functional outcomes at hospital discharge and mortality at 6 months after injury in TBI patients with intracranial hemorrhage or diffuse axonal injury [42]. The gene discussed is MYD88; the disease is intracranial hemorrhage.