It must be noted that, although the inflammatory infiltrate in EoE is eosinophil-predominant, several other cells and cytokines including mast cells, immunoglobulin (Ig) G4, periostin, and eotaxin-3 contribute to the inflammatory process of the esophagus in affected patients [3]. The gene discussed is CCL26; the disease is eosinophilic esophagitis.