Recently, a second meta-analysis was published, which investigated the diagnostic accuracy of 2-HG MR spectroscopy for the determination of IDH status in subgroups of lower-grade gliomas and glioblastomas, respectively, which confirmed high sensitivity (93% (95%CI 58–99%)) and specificity (84% (51–96%)) for both cohorts [16]. This evidence concerns the gene IDH2 and central nervous system cancer.