Moreover, obesity may increase osteoclastogenesis and bone resorption through upregulating proinflammatory cytokines, such as IL-6 and TNF-α, which are capable of stimulating osteoclast activity through the RANKL/RANK/OPG pathway [37,38,39]. The gene discussed is TNFSF11; the disease is obesity due to melanocortin 4 receptor deficiency.