SMAD3 and carcinoma of esophagus: In oesophageal cancer, ATP-binding cassette, sub-family B (MDR/TAP), member 7 (ABCB7) knockdown inhibits TGF-β signalling pathway transduction by promoting SMAD7 expression and repressing SMAD3 expression, inducing apoptosis and suppressing EMT in oesophageal cancer cells [30].