In a study by Siekmann et al. patient-derived xenograft ALL (PDX-ALL) models were established with dependencies on fms-like tyrosine kinase 3 (FLT3) and platelet-derived growth factor receptor b (PDGFRB), which were interrogated by phosphoproteomics using iTRAQ mass spectrometry [88]. This evidence concerns the gene FLT3 and acute lymphoblastic leukemia.