[39] evaluated the effect of yerba mate tea extract in vitro and in vivo models of ethanol-induced liver injury in rats and obtained positive results, since the extract was able to supply the increase in cell death by inhibiting the cytochrome p450 2E1 (CYP2E1) activity, leading to the conclusion that yerba mate tea extract can prevent alcohol-induced liver damage. Here, CYP2E1 is linked to injury.