An amount of 10% w/w FO feeding in SD rats with type 2 diabetes significantly decreased plasma inflammatory indicators (IL-1β, IL-10, IL-17A, IL-6, and TNF-α) and LPS levels, which was similar to the present study where we observed the anti-inflammatory action with both 7% w/w and 10.5% w/w FO feeding by reducing hepatic TNF-α and IL-1β levels. The gene discussed is TNF; the disease is type 2 diabetes mellitus.