Amounts of 10%, 20%, and 30% w/w FO replacement for 16 weeks dose-dependently ameliorated systemic insulin resistance and reversed hepatic inflammation via downregulating the gene expression of TNF-α, IL-6, IL-1β, and MCP-1 in high-fat-diet mice [46], which differs from the present study where a lower dose with 7.0% w/w FO feeding showed a better anti-inflammation potential. This evidence concerns the gene CCL2 and Insulin resistance.