Besides, following DDP treatment, there was a decreased PAPSS1 staining in the ovarian tumor xenografts derived from sh-PAPSS1 transfected A2780 and SKOV3 cells compared with the shSCR transfected A2780 and SKOV3 cells, suggesting that enhanced efficacy of cisplatin treatment in cells with suppressed PAPSS1 expression(Fig. 5A, B). This evidence concerns the gene PAPSS1 and ovarian neoplasm.