SNAP25 and Creutzfeldt Jacob disease: In recent studies, CSF SNAP-25 and Ng levels yielded a high diagnostic accuracy in distinguishing CJD from other neurodegenerative disorders [21–24]; however, no studies have ever evaluated their diagnostic value in the clinical setting (i.e., against other rapidly progressive neurological syndromes) and the influence of the CJD subtype on biomarker levels.