When considering the whole CJD cohort, CSF SNAP-25 was significantly associated with survival (HR 1.71 [1.48–1.99], P < 0.001), even after accounting for covariates known as prognostic factors in prion disease as codon 129 genotype, age at LP and time from onset to LP. The gene discussed is SNAP25; the disease is Creutzfeldt Jacob disease.