In ROC curves analysis, CSF SNAP-25 and Ng yielded a diagnostic accuracy of respectively 90% (area under the curve [AUC] 0.902 [0.873–0.931]) and 69% (AUC 0.697 [0.626–0.767]) in discriminating between CJD and np-RPD. Here, SNAP25 is linked to Creutzfeldt Jacob disease.