For example, our previous studies demonstrated that circRIMS1 and circPPP1CB could serve as miRNA sponges to regulate bladder cancer progression [18, 19]; circRHOBTB3 is an endogenous competitive RNA for miR-654-3p to suppress gastric cancer growth [39]; the circNSD2/miR-199b-5p regulatory axis was confirmed to be involved in the progression of colorectal cancer [40] and hsa_circ_0003258 regulates prostate cancer progression by binding to miR-653-5p and modulating IGF2BP3 expression [41]. This evidence concerns the gene IGF2BP3 and gastric cancer.