We provided some evidences to support this concept, for example, the membrane-encapsulated NPs still induced anti-tumor immune responses and significantly suppressed tumor growth even if the specific tumor antigen E744-62 was not carried by the NPs (Fig. 6), implying the antigenicity of TC-1 tumor cells; and the inclusion of E744-62 further enhanced the induced antitumor immunity with a broad antigen spectrum, which was evidenced by the increased responses to not only E744-62 and also ICD membrane components. The gene discussed is GNPTAB; the disease is neoplasm.