Notably, recently reports have shown that SIRT2 protein is upregulated in the brain tissue of a mouse model with transient middle cerebral artery occlusion [27].The overexpression of SIRT2 protein after ischemic stroke may have contributed to the increased SIRT2 concentration in AIS serum exosomes which was found in this study. The gene discussed is SIRT2; the disease is androgen insensitivity syndrome.