As lower Ang-2 levels were predominantly found in tumors that had spread throughout the peritoneal cavity and higher levels correlated with tumor growth restricted to the retroperitoneal lymph nodes, this might be related to intraperitoneal metastases being a greater challenge to be removed completely (Horowitz et al. 2015; Coccolini et al. 2013). The gene discussed is ANGPT2; the disease is neoplasm.