These KEGG pathways are mainly involved with immunological responses (such as B-cell receptor signaling pathway, primary immunodeficiency, chemokine signaling pathway, hematopoietic cell lineage, cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, allograft rejection, the intestinal immune network for IgA production) and cellular signaling (such as apoptosis, insulin signaling pathway, MAPK signaling pathway, focal adhesion, dilated cardiomyopathy, cell adhesion molecules (CAMs), ubiquitin-mediated proteolysis, and vasopressin-regulated water reabsorption) (Fig. 3C). The gene discussed is INS; the disease is dilated cardiomyopathy.