The pathways included cholesterol homeostasis, steroid biosynthesis, metabolic pathways, AGE-RAGE signaling pathway in diabetic complications, lipid and atherosclerosis, PPAR signaling pathway, regulation of lipolysis in adipocytes, VEGF signaling pathway, insulin resistance, sphingolipid signaling pathway, insulin signaling pathway, diabetic cardiomyopathy, phosphatidylinositol signaling system, glycerolphospholipid metabolism. The gene discussed is INS; the disease is diabetic cardiomyopathy.