Network analysis revealed a positive correlation between Cybb and the inflammatory genes Casp1 and Naip2. BP GO analysis identified Cybb in the positive regulation of angiogenesis, and KEGG pathway analysis identified Cybb in the lipid and atherosclerosis, AGE-RAGE signaling pathways in diabetic complications, and diabetic cardiomyopathy pathways. Here, CYBB is linked to diabetic cardiomyopathy.