TTR and Hypertension: The DGIdb gene–drug interaction tool also identified the hypertension drugs reserpine and atenolol as targets for Ptgs2. Transthyretin (Ttr) (the most down-regulated gene in both datasets), had nine drug interactions identified with several of the drugs used for transthyretin-mediated amyloidosis (tafamidis, tafamidis meglumine, inotersen, patisiran).