CASP1 and cardiovascular disorder: Since Cybb was altered in both datasets, involved in several pathways at the intersection of diabetes and cardiovascular disease, and was the target of several drugs, expression network analysis was performed to identify genes positively and negatively correlated with Cybb. In the positive correlation map, several genes involved in lipid metabolism and inflammation including Plaur (0.796), Irak3 (0.785), Prdx5 (0.855), Casp1 (0.802), and Naip2 (0.784) displayed a positive relationship with Cybb (Fig. 7A).