For BC, cytokeratin-19 (CK19), high-mobility group box-1 (HMGB1), E-cadherin, carbohydrate antigen 15–3 (CA15-3), 19–9 (CA19-9), 125 (CA125), carcinoembryonic antigen (CEA), tissue polypeptide-specific antigen (TPS), soluble fragment of cytokeratin 19 (CYFRA21-1), and mucin-like carcinoma-associated antigen (MCA) have been reported as predictive and prognostic markers13–19. This evidence concerns the gene HMGB1 and breast cancer.