The AUC values of ROC curves were 0.987 of CHSY1, 0.731 of DPYD, 0.971 of IMP4, 0.992 of MAD2L2, 0.987 of MAPKAPK2, 1.000 of PRPF4, 0.954 of SLC9A1, 1.000 of SLC20A1, and 0.924 of TIPRL (Supplementary Fig. 1A–I), demonstrating that these hub genes enabled to diagnose AD. Here, DPYD is linked to Alzheimer disease.