As shown in Fig. 5E, in the AD dataset, the SLC9A1, IMP4, MAPKAPK2, CHSY1, SLC20A1, MAD2L2, and PRPF4 had a significant positive association with the Xenobiotic metabolism pathway, while TIPRL had a significant negative association with it. The gene discussed is MAD2L2; the disease is Alzheimer disease.