EIF2AK3 and cancer: The reported findings have broad physiological relevance because PERK inhibitors have been used in over 200 studies as tool compounds to shed light on the function of the ISR, as well as to evaluate the therapeutic potential of its inhibition in various diseases, from cancer to neurodegeneration (https://pubmed.ncbi.nlm.nih.gov/?term=%28%28GSK2606414%29+OR+%28GSK2656157%29%29+OR+%28AMG44%29).