Whereas anti-OX40/anti-PD-L1 therapy had no effect on melanoma growth, two cycles of FMD plus anti-OX40/anti-PD-L1 caused a strong delay of tumor progression, although most of the effect appears to be caused by the dietary intervention since FMD plus anti-OX40/anti-PD-L1 only caused a non significant trend for improved anti-cancer effects compared to FMD alone (Fig. 2B, C). This evidence concerns the gene TNFRSF4 and melanoma.