Although FMD did not modify the percentage of immune infiltrated CD8 and CD4 T cells in the various experimental groups, the IHC analysis of the tumor sections showed that FMD only in combination with anti-OX40/anti-PD-L1 promotes CD8 T cells infiltration into the tumor center (Supplementary Fig. 4A, B), but it does not affect CD4 T cells (Supplementary Fig. 4C). This evidence concerns the gene CD4 and neoplasm.