This study showed PC3 (prostate) and Kelly (neuroblastoma) cell lines expressed nfP2X7 and low levels of P2X7, whereas SK-MEL-5 (melanoma) expressed high levels of P2X7 and low levels of nfP2X7, highlighting a generally inverse relationship between P2X7 and nfP2X7 surface expression. Here, P2RX7 is linked to melanoma.