Individuals with both CHIP and non-overlapping autosomal mCAs (N = 386) demonstrated a strong positive association with both incident lymphoid malignancy risk (hazard ratio (HR) = 8.63, 95% confidence interval (CI) = 5.93–12.58, P = 3.09 × 10−29) and incident myeloid malignancy risk (HR = 24.70, 95% CI = 14.82–41.16, P = 7.98 × 10−35) compared to individuals without CHIP or autosomal mCAs (Supplementary Fig. 11). This evidence concerns the gene STUB1 and myeloid neoplasm.