Ambigram discovers 85 recurrent FBIs or complex BFB polymorphisms (occurring in more than 5% of the samples in the cohort) in 923 whole genomes from the 1000 Genome Project (1000GP), directly truncating 32 genes, including APP, C4BPA, and SUGCT. We apply Ambigram to 330 congenital heart disease (CHD) probands and 612 of their parents, with 923 1000GP samples as unaffected controls. The gene discussed is APP; the disease is coronary artery disorder.