The three genes that are most frequently implicated in FBIs are APP, C4BPA, and BORCS5. We find that PTPRQ, PUS7, ITPRID1, PLEKHB2, IL1RAPL1, and EXT1 that carry FBI or complex BFB polymorphisms are significantly (p value < 1e-5) related to CHD. The gene discussed is IL1RAPL1; the disease is coronary artery disorder.