The three genes that are more frequently (>50%) involving FBIs are APP, C4BPA, and BORCS5. We find that PTPRQ, PUS7, ITPRID1, PLEKHB2, IL1RAPL1, and EXT1 that carry FBI or complex BFB polymorphisms are significantly (p value <1e-5) related to CHD. The gene discussed is C4BPA; the disease is coronary artery disorder.