TRPM3 and Intellectual disability: Further, Hypotonia (79%) and Global developmental delay (66%) were also frequently observed among patients with variants in TRPM3. Intellectual disability at various levels of severity (mild, moderate, or severe) was already reported in 95% of the patients (19 of 20 patients, whose age was 5 yr or more) with variants in TRPM3. In our patient, we observed severe intellectual delay.