At both ages, we observe significant 18-h fasting hypoglycemia in HttLKO/LKO compared with Htt+/+ mice (Fig 2F, ages pooled for plotting, 27% reduction; N = 18 Htt+/+, 22 HttLKO/LKO, t test t(29.9) = 2.2; P = 0.036). Here, HTT is linked to Hypoglycemia.