Consistent with the different phenotypes of M1/M2 versus M4/M5 AML blasts ex vivo, FLT3 status had no apparent impact on PARP1 expression by M1/M2 AML (Figure 5F), and no correlation between PARP1 expression (or other known parthanatos-mediating genes) and survivability was observed for M1/M2 AML (Figure S7). The gene discussed is PARP1; the disease is acute myeloid leukemia.