In non-inflammatory AMN patients, neither IL-15, IL12-p40, nor CCL7 were increased compared with healthy controls of similar age (Fig. 3), possibly pointing to a role of an X-ALD immanent, pro-inflammatory primed activation state in asymptomatic X-ALD patients during a critical time window in childhood/adolescence, when peak onset of CALD occurs. The gene discussed is IL15; the disease is X-linked adrenoleukodystrophy.