In line with the findings for pro-inflammatory cytokines but also adiponectin, SFC-fed TNFα−/− mice were also markedly protected from the development of glucose intolerance and impairments of insulin signaling in liver tissue e.g., alterations of expression of Irs1 and Irs2. It has been shown before that targeting TNFα through antibodies or knocking out its receptors glucose tolerance can be improved in rodent models [44,45]. This evidence concerns the gene IRS2 and Glucose intolerance.