Results of the present study also suggest that in mice in settings of diet-induced non-obese MASLD, TNFα is not a regulator of intestinal permeability but rather seems to trigger the induction and release of other inflammatory markers such as IL1β, IL6 and NO2− through JNK-dependent signaling cascades in the liver. This evidence concerns the gene MAPK8 and metabolic dysfunction-associated steatotic liver disease.