Somewhat contrasting our findings but also some of the previous studies reporting that a loss of TNFα may improve glucose tolerance in settings of MASLD and diabetes type 2, it has been shown by Wu et al. that a downregulation of TNFα in TNFR1/TNFR2 double knockouts employing an Adenovirus-associated virus-shRNA TNFα worsened glucose homeostasis [44], further suggesting that TNFα may be pleiotropic. This evidence concerns the gene TNFRSF1B and metabolic dysfunction-associated steatotic liver disease.