Taken together our results suggest that an inhibition or genetic deletion of TNFα in settings of diet-induced non-obese/lean MASLD may diminish the development of MASLD and insulin resistance in mice and that this is associated with a protection from the induction of pro-inflammatory cytokines, and alterations in adiponectin signaling. The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatotic liver disease.