Divided the PMOP patients into two groups based on the expression of ROCK1, the GSEA analysis illustrated that “adaptive immune response”, “regulation of cell activation”, “external side of plasma membrane”, “plasma membrane protein complex”, and “side of membrane” were enriched in low-ROCK1 group and while KEGG pathways including “cytokine receptor interaction”, “hematopoietic cell lineage”, and “primary immunodeficiency” were highly related to low expression of ROCK1 in PMOP patients. Here, ROCK1 is linked to inborn error of immunity.