Besides, we investigated the correlation between AKAP8L and the prognosis of distinct clinical subgroups of KIRC (OS, DSS and PFI), and observed a higher AKAP8L expression as well as the worse OS in subgroups with an age > 60, white race, lower serum calcium and hemoglobin, no lymphatic metastasis (N0), distant metastasis (M1), clinical tumor staging of T3-T4, histologically graded G3-G4 and pathologically graded Stage III-IV, as demonstrated in Figure 8A–8H. This evidence concerns the gene AKAP8L and neoplasm.