Additionally, single nucleotide polymorphisms that are located at the genetic loci including GCKR, ANGPTL3, MLXIPL, SORT1, HMGCR, and ABO were found to be associated with plasma TG and LDL cholesterol levels [41,42], and high levels of plasma LDL cholesterol and TG are widely known as an independent risk factor for cardiovascular disease [43,44]. This evidence concerns the gene GCKR and cardiovascular disorder.