Moreover, the pathogens could colonize at atherosclerotic plaque, pericarditis or myocardial tissue after enter blood, which could affect the occurrence and development of coronary heart disease, occurrence and development of coronary heart disease [69–71]; (2) Porphyromonas gingivalis, as one of the main pathogens of PD, it can induce the expression of platelet aggregation and intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and P-selectin. This evidence concerns the gene SELP and coronary artery disorder.