Combinatorial use of RNAseq with species-specific mapping, spatial transcriptomics, immunohistochemistry and 2D DIGE, MALDI-TOF/TOF mass spectrometry provided a holistic understanding of a major mechanism coordinating escape from oxidative stress in lymphatic intravascular metastatic niches when HLTF expression is silenced in tumor cells and cells of the TME. Here, HLTF is linked to neoplasm.