INS and type 2 diabetes mellitus: The lipid profileof endosomes is dominated by bis(monoacylglycero)phosphate (BMP),an anionic lipid that is critically important for endosomal fusion.37,38 In late endosomes, BMP constitutes 77% of the total lipids.39 Expanding upon this, we investigate the roleof this lipid, as well as the 77:23 mol/mol BMP/PC mixture, whichrepresents the composition of late endosomes in insulin aggregation.40,41 Insulin aggregation is observed upon diabetes type 2 and injectionamyloidosis.42 In a former case, the overproductionof insulin in the pancreas results in its aggregation.