The accuracy of the new model with features selected from a combination of the RS, Alzheimer’s Disease Assessment Scale (ADAS) and apolipoprotein E (APOE4), achieved an AUC of 0.867, higher than that achieved for a RS model alone (0.828), or using the ADAS (0.720) and APOE4 (0.591) alone. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.