We identified 340 mL/min/m2 as the threshold DO2i associated with reduced CS-AKI risk in neonates undergoing STAT category 4 and 5 procedures and 400 mL/min/m2 as the threshold DO2i associated with reduced CS-AKI risk in infants undergoing STAT category 1–3 procedures. The gene discussed is SOAT1; the disease is Cowden syndrome 1.