A study found that the serum cytokeratin-19 fragment (CYFRA 21-1) had higher specificities than CA19-9 for ICC but was not routinely used.[26] Several studies have reported that oncogene and noncoding RNA expression are associated with ICC.[27–29] There has not been enough evidence to support the use of gene testing for the diagnosis of ICC. Here, KRT19 is linked to intrahepatic cholangiocarcinoma.