STAT3 enhanced anoikis resistance, facilitated cell invasion, and enhanced pancreatic cancer cells’ capacity to metastasize, as reported by Fofaria and Srivastava.[36] Researchers have identified some prognostic signatures for HNSCC in recent years.[21–25,37] However, to our knowledge, few have investigated the relationship between anoikis and HNSCC. Here, STAT3 is linked to pancreatic neoplasm.