PROS1 and pancreatitis: The genetic risk factors associated with asparaginase-associated pancreatitis in pediatrics that have been found are PRSS1, Unc-51 like autophagy activating kinase 2, regulator of g protein signaling 6, Carboxypeptidase A2, 4-hydroxy-2-oxoglutarate aldolase 1, metallopeptidase with thrombospondin type 1 motif 17, Myb-binding protein 1A, sperm antigen with calponin homology and coiled-coil domains 1, asparagine synthetase (glutamine-hydrolyzing) and cystic fibrosis transmembrane conductance regulator.[26,27] Our patient had a mutation in the PRSS1 gene, encoding cationic trypsinogen (Fig.5).