IL5 and brain ischemia: The first-line drug of choice is prednisone (starting dose of 1 mg/kg/day).[14] Hydroxyurea is an effective agent which may be used in conjunction with corticosteroids or in steroid nonresponders.[12] Other therapeutic options are anti-IL-5 monoclonal antibodies (mepolizumab), interferon-α, cyclophosphamide, and leukapheresis.[12] In addition, IHES-induced cerebral ischemia requires antithrombotic therapy that includes anticoagulation and antiplatelet treatments in addition to immunotherapy.