Altogether, BUB1 is a potential tumor-promoting gene and partly renders prostate cancer cells the docetaxel resistance via circ_0004087/SND1/MYB/BUB1 axis.[26] CCNA2 is a type of cycling protein, which was first detected in primary liver cancer cells, which appeared in the late G1 and could bind to CDK2 and CDC2.[27] In PCa, CCNA2 was significantly associated with biochemical recurrence, disease-free survival and overall survival rate of PCa patients. This evidence concerns the gene BUB1 and Familial prostate cancer.