VHL and familial pancreatic carcinoma: Notably, co-expression of CDC20 and UBE2S can enhance EMT in pancreatic cancer cells via the VHL/HIF-1α/STAT3 pathway.[54] UBE2S downregulated the expression level of VHL through ubiquitin, forming a ubiquitin complex with VHL and HIF-1α and regulating the transcription factor STAT3.