CDC20 and Familial prostate cancer: High expression of CDC20 was positively correlated with sex, poor tumor differentiation, large tumor size, lymph node invasion, distant metastasis, advanced TNM stage, and cytokine levels in breast cancer,[32] HCC,[14,33] GC,[22,34] CRC,[16] epithelial ovarian cancer.[20] In addition, CDC20 overexpression was associated with advanced age, high grade, non-papillary growth pattern in bladder cancer patients,[18] and Gleason score, vesicle invasion, and biochemical recurrence in prostate cancer,[19] indicating that CDC20 expression is an independent prognostic factor.