TNFAIP3 and cancer: For example, migration and invasion inhibitor protein suppressed APC-mediated Cyclin B1 degradation by interacting with CDC20, thereby inhibiting glioma development and progression.[36] CDC20 is negatively regulated by miR-1321 and miR-7515 to suppress NSCLC cell migration and invasion.[41] CDC20 also promotes the migration of triple-negative breast cancer cells, and CDC20 inhibitors would block cancer cell growth and migration.[65] The function of CDC20 in breast cancer is regulated by REC8 and the A20/TNFAIP3-CDC20-ASP1 axis.