TP53 and hepatocellular carcinoma: CDC20 can also regulate the radiosensitivity of P53 mutant HCC cells through the Bcl-2/Bax pathway.[49] In addition, knockdown of CDC20 enhanced the cytotoxicity of paclitaxel and increased the effect of gamma irradiation against pancreatic carcinoma cells.[80] CDC20 could also induce the radioresistance of bladder cancer cells by targeting FOXO1 degradation, indicating that the inactivation of CDC20 might be a potential strategy to overcome radioresistance in bladder cancer.[58] Recently, several studies have shown that CDC20 is associated with chemosensitivity in prostate cancer.