CDC20 and hepatocellular carcinoma: For example, CDC20 overexpression is involved in TMZ-resistant glioma cells with epithelial-mesenchymal transition (EMT).[38] In addition, miR-1321 and miR-7515 can suppress NSCLC cell EMT by targeting CDC20.[41] CDC20 silencing increased the expression levels of E-cadherin, decreased the expression levels of N-cadherin, vimentin, and Ki-67, and inhibited migration and invasion of HCC cells.